The Kamuzu University of Health Sciences (KUHeS), Formerly Kamuzu College of Nursing (KCN) and College of Medicine (COM), is a comprehensive health and allied sciences higher learning institution with the primary function of training health workers. Its mission is “to be an academic centre of excellence in the training of doctors and other health professionals in clinical service and medical research, responsive to the health needs of Malawi and its neighbours within the Southern African region”. Through postgraduate training, KUHeS expects to develop and mentor clinicians, public health practitioners and scientists who will become leaders and game-changers in their areas of speciality to transform the health sector in Malawi and globally. Since 2015, the National Institutes of Health-Fogarty International Centre in the USA has been funding the KUHeS and University of North Carolina to establish and roll-out the Malawi HIV Implementation Science Research Training (M-HIRST) Program which aims at building and strengthening local capacity for conducting Implementation research studies to generate evidence that accelerates the scale up of evidence-based HIV interventions.